Lisomucil Tosse Sciroppo Sedativo 100ml

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Description

Description Lisomucil Cough Sedative syrup 100mldenomination: Lisomucil sedative cough 15 mg / 5 ml syrup
Pharmacotherapeutic category: Broncopulmarari.
Active principles: Destromethfano bromydrate.
Excipients: sucrose, 70% sorbitol, methyl-hydroxybenzoate, a-hydroxybenzoate par propose, orange aroma, purified water.
Indications: symptomatic treatment of cough.
Contraindications / EFF.Secondar: hypersensitivity to the active ingredient or to any of the eccipien listed; Contrained in children of age under the age of 6, n Elle women pregnant and during lactation.The Medicin Ale is contraindicated: in asthmatic patients, in patients suffering from respiratory failure, in case of contemporary treatment or in the LE Two weeks after therapy with antidepressant medicines Ti Po Mao Inhibitors (IMAO). It is contraindicated the intake of alcohol hard therapy.
Posology: The dosage must be halved for elderly patients or in case of renal and / or hepatic sufficiency. Adults and adolescents over 15 years: 5-10 ml of syrup (equivalent to 15-30 mg of destromethorphan), 3-4 V Olte a day (respecting a minimum interval of 6-8 hours between two soams). The maximum daily dose is 40 ml of syrup (equivalent to 120 mg of destromethorphan) .Bells and adolescents from 6 to 15 years: 2 , 5-5 ml of syrup (equivalent to 7.5-15 mg of destromet orphan) 3 times a day (respecting a minimum interval of 8 hours t two administrations). The maximum daily dose is 15 ml of s piroppo (equivalent to 45 mg of destromethorphan). Use the dosing teaspoon for the administration of the medicinal product. The medicine must be sized preferably after meals. Use the non-diluted medicine or. Do not pass the recommended doses.
Storage: Store at a temperature below 25 degrees C; Keep the container and tight and away from light.
WARNINGS: Before starting a cough treatment, you should study the causes that require specific etiological treatment. Non us are for prolonged treatments over 5-7 days: after this period of treatment at the usual dose without appreciable results, The dose must not be increased. Production cough, being a senial factor of bronchopulmonary defense, should not be suppressed. The concomitant use of an expectorant medicine or Macles to treat cough treatment is not rational. co n Caution in subjects with altered hepatic and / or renal function. For elderly patients and in the event of hepatic insufficiency and / or renal insufficiency: the initial dose must be reduced by 50% and can ‘may be increased in operation of the tolerability and neither ceased. It has sucrose and sorbitol. .A Folding of prolonged use, patients can develop tolerance to the medicinal product, as well as mental and physical dependence. Cases of abuse of DESTROMETORFANO.SI have been reported. Please note particular attention with teenagers, young adults and baby I, nonche ‘With patients with a history of alcoholism, abuse of Farma CI or psychoactive substances. Patients with a trend towards abuse or slope must take the medicine for short periods. The destromet orphan is metabolized by hepatic cytochrome P450 2D6.L ‘Activities’ of this enzyme is genetically determined. 10% of the population is a slow metabolizer for the CYP2D6.in metabolisers the NTI and patients with concomitant use of CYP2D6 inhibitors can but nudish exaggerated and / or prolonged effects of the Destrometelfano ITORI CYP2D6 can increase and prolong the effects of destromethorphan.
Interactions: The association of drugs containing monoaminoxidase inhibitors (IMAO) and DESTROMETORFO can be lethal, with the appearance of Rigid Ita ‘muscle, hyperpiresia, ipereccitability, apnea and laryngospasmo .alcool: reduced supervision can be dangerous for the vehicle guide or use of machinery. The consumption of alcoholic beverages must be avoided during treatment. >> Interactions that must be in consideration. Other substances that depress the Nervos or Central system (analgesic opioodi, some antidepressants, NTI H1- antihistamines, barbiturates, benzodiazepines, clonidine and related products, hypnotic, neuroleptic drugs, dearthly from benzodiazepi ne): upgrading of the depression of the central nervous system. A reduced supervision can be dangerous for driving vehicles or use of machinery.Other morphine derivatives (analgesics or sedatives of cough): respiratory depression (strengthening of EPRES effects SIVI of morphine derivatives), especially in the old patient or. >> drugs in whose metabolism intervenes cytochrome CYP2D6.Inibi Tori of the CYP2D6: Destromethorphan is metabolized by CYP2D6 and has a wide metabolism of first passage. The concomitant use of Powerful inhibitors of the enzyme CYP2D6 can increase the concentrations of DESTR Oomethorfano in the body at levels of many times greater than the Normal value Ale.cio ‘increases the risk for the patient of toxic effects of the de strometelf (agitation, confusion, tremor, insomnia, Diarrhea and Respiratory Pressure) and of the development of serotonin syndrome.PO CYP2D6 inhibitory trees are fluoxetine, paroxetine, quinidine and te rbinafina.In concomitant use with quinidine, destromethorphan fmatica concentrations increased up to 20 times, with as a raising increase in adverse effects on the central nervous system of the agent. Also amiodarone, flecainide and propafenone, sertraline, buprop ion, methadone, cin Acalcet, Aloperidolo, Perfenazina and Tioridazine Han No similar effects on the metabolism of destromethorphan.se It is necessary or the concomitant use of CYP2D6 and Destromethorphan inhibitors, the patient must be monitored and it may be necessary to reduce the dose of destromethorphan. Possible interaction with fluoxetine, p aroxetine, sertraline, fluvoxamine, amiodarone, chinidine and aloperidol or ‘confirmed that fluoxetine can inhibit metabolism d and destromethorphan and consequently constitutes a risk of morphino-simile action. The reverse reaction is also Possible with the rifchio of onset of a serotonergic syndrome (mint confusion, agitation, hyperflexia, hyperthermia, sweating, mioclonie). The destromethorphan must be used with caution in patients who sume serotoninergic drugs such as monoaminoxid asi inhibitors (imao) or selective serotonin reuptake (SSRI) (eg Fluoxetine and Paroxeti NA) due to increased risk of tonnes of serotonin (serotonin , the reduction of the rif it of the cough can lead to a (severe) accumulation of mucus.
Undesirable effects: The following list shows adverse reactions that may occur. Frequency classes are defined as follows: Very common (> = 1/1 0); common (> = 1/100, <1/10); Uncommon (> = 1/1000, <1/100), rare (> = 1 / 10.000, <1 / 1,000), very rare (<1 / 10,000; including isolated cases), not note.patologies of the skin and of the subcutaneous fabric.comune: itching; Not note: rash, angioedema, urticaria, eruption f Issa from drugs. Respiratory, thoracic and mediastinicaps.no n Note: Broncospasmo.Peartings. Note: Midriary (in itself due to the intake of high doses). Gastrointestinal diseases. MMO LTO Municipality: nausea, vomiting, constipation.Pompathologie Nervos system O.very common: sleepiness, dizziness; Not note: Diandria, Nistagmo, Distonia (especially in children), agitation (following the assunz ion of high doses). Ear and labyrinthaps an aphi-optical. Psychiatricistribes.comune: Confusion State; A lot of R ARO: abuse and dependence on destromethorphan; Not known: Hallucination, of psychotic hum. Systems and conditions related to SED and administration.Comunist: fatigue Continuous de l Report benefit / risk of the medicine. Pregnancy and lactation: Destromethorphan is not teratogenic: perspective studies in a number the imitated women did not show a teratogenic risk. However, the administration of destromethorphan must be avoided during the pregnancy three months. ADMINING OF DESTROMETORFO TO THE MOTHER CAN CAUSE THE PENSOMEN OF DEPRESSION RESPIRATORY IN THE NEWSHOUSE Maternal milk. Some cases of hypotonia and respiratory breaks are described in newborns after the mother had taken other nti-cough medicines with middle-acting doses higher than therapeutic therapeutic.Q uindi this medicine is contraindicated during breastfeeding.